When using a Card OS 4.2 card, everything seems to work fine, but not with v5.0 cards.
As promised, here is some diagnostic data on using OpenSC with my CardOS 5.0 card.

CardOS V5.3 is a multifunctional native smart card operating system, which is extendable by customized packages to amend or adjust the operating system functionality. In addition the authentication framework is a flexible option to realize authentication protocols by using configuration data. In the details pane, double-click Windows Components, and then double-click Smart Card. Right-click Turn on Smart Card Plug and Play service, and then click Edit. Click Disabled, and then click OK.

The current page applies to CardOS API version 3.2.007 alone. Click on the links below for other CardOS API versions: 3.2.039; 3.2.040; 3.2.042; 3.2.013; 3.2.041; Some files, folders and Windows registry entries can be left behind when you are trying to remove CardOS API from your computer.

cardos-tool -i seems fine; it says

3b:d2:18:00:81:31:fe:58:c9:01:14
Info : CardOS V5.0, 2012
Serial number: 02 02 36 cd 00 07 27 4c
OS Version: 201.1 (that's CardOS V5.0)
Current life cycle: 16 (operational)
Security Status of current DF:
Free memory : 579
ATR Status: 0x0 ROM-ATR
Packages installed:
E1 0B 53 06 03 04 13 02 C9 01 8F 01 01 ..S..........
Ram size: 7, Eeprom size: 96, cpu type: 78, chip config: 63, chip manufacturer: 5
Free eeprom memory: 74096
Current Maximum Data Field Length: 640
Complete chip production data:
CC 78 33 3A 01 00 01 00 0E 00 00 01 0B 02 02 36 .x3:...........6
CD 00 07 00 27 00 4C 61 75 37 37 FF FF FF FF 78 ....'.Lau77....x
01 51 40 78 05 16 07 00 00 83 12 05 E7 55 21 02 .Q@x.........U!.
01 00 00 00 00 00 00 00 00 00 00 00 00 00 00 00 ................
00 00 00 00 00 00 00 00 00 00 00 00 ............
System keys: PackageLoadKey (version 0x00, retries 10)
System keys: StartKey (version 0x00, retries 10)
Path to current DF:
50 15 50 75 4B 07 P.PuK.

This output is also attached:cardos-tool_-i_output.txt and comes with debug trace cardos-tool_-i_debug.txt

pkcs11-tool -I seems fine; it says

Cryptoki version 2.20
Manufacturer OpenSC (www.opensc-project.org)
Library Smart card PKCS#11 API (ver 0.0)

with debug trace pkcs11-tool_-I_debug.txt and spy trace pkcs11-tool_-I_spy.txt

pkcs11-tool -L gives strange output:

Available slots:
Slot 0 (0xffffffff): Virtual hotplug slot
(empty)
Slot 1 (0x1): O2Micro CCID SC Reader 0
token label : (null)
token manufacturer :
token model : PKCS#15
token flags : token initialized
hardware version : 0.0
firmware version : 0.0
serial num :

with debug trace pkcs11-tool_-L_debug.txt and spy trace pkcs11-tool_-L_spy.txt

pkcs11-tool -O does not find any objects (empty output),
with debug trace pkcs11-tool_-O_debug.txt and spy trace pkcs11-tool_-O_spy.txt

Upon request I can provide further debug data.

• Driver type: SmartCard
• Vendor: cv cryptovision GmbH

Cardos Api Windows 10 64

• Version: 1.0.0.133 (15 Jun 2009)
• *.inf file: cvmd.inf

Cardos Api V5.3

CardOS API Minidriver drivers were collected from official websites of manufacturers and other trusted sources. Official driver packages will help you to restore your CardOS API Minidriver (card readers). Download latest drivers for CardOS API Minidriver on Windows.

Win32 Api